The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 23, 2012
Filed:
Nov. 05, 2009
Bernd Buettelmann, Schopfheim, DE;
Simona Maria Ceccarelli, Basel, CH;
Georg Jaeschke, Basel, CH;
Sabine Kolczewski, Rheinfelden, DE;
Richard Hugh Philip Porter, Reinach, CH;
Paul Spurr, Riehen, CH;
Eric Vieira, Frenkendorf, CH;
Bernd Buettelmann, Schopfheim, DE;
Simona Maria Ceccarelli, Basel, CH;
Georg Jaeschke, Basel, CH;
Sabine Kolczewski, Rheinfelden, DE;
Richard Hugh Philip Porter, Reinach, CH;
Paul Spurr, Riehen, CH;
Eric Vieira, Frenkendorf, CH;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention relates to diazole derivatives of the general formula wherein A, E, R, Rand Rare as defined in application and pharmaceutical compositions containing them. The invention also relates to use of such compounds for the treatment of diseases mediated by the metabotropic glutamate receptors (mGluR), such as anxiety, chronic and acute pain, protection against liver damage, urinary incontinence, obesity, Fragile-X and autism, Alzheimer's disease, epilepsy, schizophrenia, ischemia, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia caused by AIDs, and Parkinson's disease.