The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2012
Filed:
Apr. 25, 2011
Peter A. Carr, Medford, MA (US);
Brian Y. Chow, Cambridge, MA (US);
Joseph M. Jacobson, Newton, MA (US);
David W. Mosley, Cambridge, MA (US);
Christopher Emig, Napa, CA (US);
Peter A. Carr, Medford, MA (US);
Brian Y. Chow, Cambridge, MA (US);
Joseph M. Jacobson, Newton, MA (US);
David W. Mosley, Cambridge, MA (US);
Christopher Emig, Napa, CA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
A method for synthesizing a nucleic acid having a desired sequence and length comprises providing a solid support having an immobilized nucleic acid, performing a nucleic acid addition reaction to elongate the immobilized nucleic acid by adding a nucleotide or an oligonucleotide to the nucleic acid, determining whether the nucleotide or the oligonucleotide is added to the nucleic acid by detecting whether there is an increase in electrophoretic force applied to the solid support when an electric field and a magnetic field gradient are applied to the support, wherein the increase in electrophoretic force applied to the support is caused by adding the nucleotide or the oligonucleotide to the nucleic acid, repeating the addition reaction and determination steps if the nucleotide or the oligonucleotide is not added to the nucleic acid, and continuing until the immobilized nucleic acid has a desired sequence and length.