The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2012
Filed:
Sep. 12, 2007
Jonathan F. Smith, Cary, NC (US);
Bolyn Hubby, Cary, NC (US);
Peter Berglund, Chapel Hill, NC (US);
Laura Copp, Raleigh, NC (US);
Whitney Ellis, Oxford, NC (US);
Jonathan F. Smith, Cary, NC (US);
Bolyn Hubby, Cary, NC (US);
Peter Berglund, Chapel Hill, NC (US);
Laura Copp, Raleigh, NC (US);
Whitney Ellis, Oxford, NC (US);
AlphaVax, Inc., Research Triangle Park, NC (US);
Abstract
The immune response to an antigen of interest, either in purified form or expressed via an alphavirus replicon particle, can be enhanced by the simultaneous administration of an alphavirus replicon particle which expresses interleukin-12. This allows for the use of significantly smaller quantities of the antigen and this immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.