The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2012
Filed:
Dec. 21, 2009
Bonnie L. Bassler, Princeton, NJ (US);
Lee R. Swem, Lawrenceville, NJ (US);
Scott M. Ulrich, Ithaca, NY (US);
Colleen T. O'loughlin, Princeton, NJ (US);
Bonnie L. Bassler, Princeton, NJ (US);
Lee R. Swem, Lawrenceville, NJ (US);
Scott M. Ulrich, Ithaca, NY (US);
Colleen T. O'Loughlin, Princeton, NJ (US);
The Trustees of Princeton University, Princeton, NJ (US);
Abstract
A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryotefrom quorum-sensing-mediated killing by the bacterial pathogen. The saving ofdemonstrates the use of these molecules as small molecule antimicrobials.