The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2012
Filed:
Jul. 18, 2008
Sailaja Pidaparthi, Cupertino, CA (US);
Yining Shi, San Jose, CA (US);
Rajiv Dua, Manteca, CA (US);
Po-ying Chan-hui, Oakland, CA (US);
Sharat Singh, Los Altos, CA (US);
Sailaja Pidaparthi, Cupertino, CA (US);
Yining Shi, San Jose, CA (US);
Rajiv Dua, Manteca, CA (US);
Po-Ying Chan-Hui, Oakland, CA (US);
Sharat Singh, Los Altos, CA (US);
Monogram Biosciences, Inc., S. San Francisco, CA (US);
Abstract
The invention provides methods and kits for detecting and/or measuring receptor homodimers on a cell surface membrane. In one aspect, the methods employ pairs of probes comprising binding compounds and a cleaving probe, such that at least one binding compound binds specifically to the same epitope of a membrane-bound analyte as the cleaving probe. The binding compound includes one or more molecular tags attached through a cleavable linkage, and the cleaving probe includes a cleavage-inducing moiety that can cleave the linkage when within a defined proximity thereto. Binding of the two probes to a homodimer of a cell surface molecules results in release of molecular tags from the binding compounds, providing a measure of formation of the homodimeric complex.