The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Mar. 27, 2003
Bornhard O. Palsson, La Jolla, CA (US);
Imandokht Famili, San Diego, CA (US);
Markus W. Covert, San Diego, CA (US);
Christophe H. Schilling, San Diego, CA (US);
Bornhard O. Palsson, La Jolla, CA (US);
Imandokht Famili, San Diego, CA (US);
Markus W. Covert, San Diego, CA (US);
Christophe H. Schilling, San Diego, CA (US);
Genomatica, Inc., San Diego, CA (US);
Abstract
The invention provides in silico models for determining the physiological function of human cells, including human skeletal muscle cells. The models include a data structure relating a plurality ofreactants to a plurality ofreactions, a constraint set for the plurality ofreactions, and commands for determining a distribution of flux through the reactions that is predictive of aphysiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. A regulatedreaction can be represented in a model of the invention by including a variable constraint for the regulated reaction. The invention further provides methods for making an in silicomodel and methods for determining aphysiological function using a model of the invention.