The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Sep. 26, 2008
John P. Toscano, Glen Arm, MD (US);
Frederick Arthur Brookfield, Abingdon, GB;
Andrew D. Cohen, New York, NY (US);
Stephen Martin Courtney, Abingdon, GB;
Lisa Marie Frost, Abingdon, GB;
Vincent Jacob Kalish, Annapolis, MD (US);
John P. Toscano, Glen Arm, MD (US);
Frederick Arthur Brookfield, Abingdon, GB;
Andrew D. Cohen, New York, NY (US);
Stephen Martin Courtney, Abingdon, GB;
Lisa Marie Frost, Abingdon, GB;
Vincent Jacob Kalish, Annapolis, MD (US);
Cardioxyl Pharmaceuticals, Hunt Valley, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.