The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2012
Filed:
Mar. 25, 2004
Toshihiro Nakashima, Kikuchi, JP;
Takumi Sasaki, Kikuchi, JP;
Kazuhiko Kimachi, Kikuchi, JP;
Shigeki Kuwata, Kikuchi, JP;
Tsukasa Nishihara, Kikuchi, JP;
Atsuko Sakata, Kumamoto, JP;
Masao Ohkuchi, Tokorozawa, JP;
Tomoyuki Koshi, Shiki, JP;
Toshiyuki Edano, Kawagoe, JP;
Toshihiro Nakashima, Kikuchi, JP;
Takumi Sasaki, Kikuchi, JP;
Kazuhiko Kimachi, Kikuchi, JP;
Shigeki Kuwata, Kikuchi, JP;
Tsukasa Nishihara, Kikuchi, JP;
Atsuko Sakata, Kumamoto, JP;
Masao Ohkuchi, Tokorozawa, JP;
Tomoyuki Koshi, Shiki, JP;
Toshiyuki Edano, Kawagoe, JP;
Juridical Foundation the Chemo-Sero-Therapeutic Research Institute, Kumamoto-Ken, JP;
Kowa Company, Ltd., Aichi-Ken, JP;
Abstract
A novel prophylactic/remedy for immunopathy is provided which is not neutralized by a neutralizing antibody to Staphylococcal enterotoxin B (SEB), known as one of superantigens, and may effectively act as a superantigen. A modified SEB having a reduced reactivity with a neutralizing antibody to SEB (anti-SEB antibody) and a prophylactic/remedy for immunopathy comprising as an active ingredient said modified SEB. The modified SEB of the present invention may be prepared with the evolutionary molecular engineering technique by introducing amino acid substitution in the amino acid sequence of SEB, especially at an epitope recognition site of the anti-SEB antibody in the amino acid sequence of SEB.