The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2012
Filed:
Sep. 04, 2009
Pamela Tan, Kulmbach, DE;
Birgit Bramlage, Kulmbach, DE;
Maria Frank-kamenetsky, Brookline, MA (US);
Kevin Fitzgerald, Brookline, MA (US);
Akin Akinc, Needham, MA (US);
Victor E. Kotelianski, Boston, MA (US);
Pamela Tan, Kulmbach, DE;
Birgit Bramlage, Kulmbach, DE;
Maria Frank-Kamenetsky, Brookline, MA (US);
Kevin Fitzgerald, Brookline, MA (US);
Akin Akinc, Needham, MA (US);
Victor E. Kotelianski, Boston, MA (US);
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK9 gene expression and the expression of the PCSK9 gene using the pharmaceutical composition; and methods for inhibiting expression of a PCSK9 gene in a cell.