The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2012
Filed:
May. 16, 2007
Harmen J. Bussemaker, New York, NY (US);
Barrett C. Foat, St. Louis, MO (US);
Ronald G. Tepper, New York, NY (US);
Harmen J. Bussemaker, New York, NY (US);
Barrett C. Foat, St. Louis, MO (US);
Ronald G. Tepper, New York, NY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
Systems and methods for determining free energy parameters for predicting binding affinities of nucleotide sequences are provided. The disclosed subject matter obtains phenotypic measurements for nucleotide sequences (for example a DNA sequence or RNA sequence), links the phenotypic measurements to the nucleotide sequences to obtain linked pairs of phenotypic measurements and nucleotide sequences, estimates a relationship between the phenotypic measurements and the nucleotide sequences using the linked pairs, and obtains sequence specific affinity parameters from the estimated relationship.