The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2012
Filed:
Feb. 14, 2008
Stefan Welzig, Vienna, AT;
Anton Gerdenitsch, Rohrbach, AT;
Jan Rothenburger, Oslip, AT;
Susanne Kolar, Neufeld/Leitha, AT;
Alexandra Scherleithner, Neufeld/Leitha, AT;
Stefan Welzig, Vienna, AT;
Anton Gerdenitsch, Rohrbach, AT;
Jan Rothenburger, Oslip, AT;
Susanne Kolar, Neufeld/Leitha, AT;
Alexandra Scherleithner, Neufeld/Leitha, AT;
Sanochemia Pharmazeutika AG, Vienna, AT;
Abstract
A process for the production of extremely pure galanthamine and galanthamine derivatives is provided. Racemic bromine narwedine is debrominated under palladium catalysis. The reaction mixture is then worked-up in the presence of oxygen or peroxides so that the palladium catalyst is converted into an insoluble form that can be easily separated. Further reaction is carried out by reduction of enantiomerically pure narwedine to form enantiomerically pure galanthamine, which is then alkylated or dealkylated, so that a corresponding substitution on the ring-nitrogen atom is achieved. By further purification, such as recrystallization, residual portions of palladium of below 5 ppm are achieved. The pure galanthamine can then be directly used as a pharmaceutical raw material.