The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2012
Filed:
Sep. 15, 2008
Anthony Calabro, Cleveland Heights, OH (US);
Lee Akst, Boston, MA (US);
Daniel Alam, Shaker Heights, OH (US);
James Chan, Cleveland Heights, OH (US);
Aniq B. Darr, Parma Heights, OH (US);
Kiyotaka Fukamachi, Mayfield Heights, OH (US);
Richard A. Gross, Plainview, NY (US);
David Haynes, Waco, TX (US);
Keiji Kamohara, Mayfield Heights, OH (US);
Daniel P. Knott, Shaker Heights, OH (US);
Hilel Lewis, Beachwood, OH (US);
Alex Melamud, Durham, NC (US);
Anthony Miniaci, Chagrin Falls, OH (US);
Marshall Strome, Gates Mills, OH (US);
Anthony Calabro, Cleveland Heights, OH (US);
Lee Akst, Boston, MA (US);
Daniel Alam, Shaker Heights, OH (US);
James Chan, Cleveland Heights, OH (US);
Aniq B. Darr, Parma Heights, OH (US);
Kiyotaka Fukamachi, Mayfield Heights, OH (US);
Richard A. Gross, Plainview, NY (US);
David Haynes, Waco, TX (US);
Keiji Kamohara, Mayfield Heights, OH (US);
Daniel P. Knott, Shaker Heights, OH (US);
Hilel Lewis, Beachwood, OH (US);
Alex Melamud, Durham, NC (US);
Anthony Miniaci, Chagrin Falls, OH (US);
Marshall Strome, Gates Mills, OH (US);
The Cleveland Clinic Foundation, Cleveland, OH (US);
Abstract
A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.