The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2012
Filed:
Mar. 16, 2009
Hans Christian Thøgersen, Mudelstrup, DK;
Michael Etzerodt, Hinnerup, DK;
Thor Las Holtet, Frederikssund, DK;
Niels Jonas Heilskov Graversen, Århus, DK;
Jette Sandholm Kastrup, Allerød, DK;
Bettina Bryde Nielsen, Greve, DK;
Ingrid Kjøller Larsen, Charlottenlund, DK;
Hans Christian Thøgersen, Mudelstrup, DK;
Michael Etzerodt, Hinnerup, DK;
Thor Las Holtet, Frederikssund, DK;
Niels Jonas Heilskov Graversen, Århus, DK;
Jette Sandholm Kastrup, Allerød, DK;
Bettina Bryde Nielsen, Greve, DK;
Ingrid Kjøller Larsen, Charlottenlund, DK;
Anaphore, Inc., La Jolla, CA (US);
Hoffmann-La Roche, Inc., Nutley, NJ (US);
Abstract
The present invention relates to the design of trimeric polypeptides using polypeptide structural elements derived from the tetranectin protein family, and their use in rational de novo design and production of multi-functional molecules including the application of the multi-functional molecules in protein library technology, such as phage display technology, diagnostic and therapeutic systems, such as human gene therapy and imaging. The trimeric polypeptides being constructed as a monomer polypeptide construct comprising at least one tetranectin trimerising structural element (TTSE) which is covalently linked to at least one heterologous moiety, said TTSE being capable of forming a stable complex with two other TTSEs; or as an oligomer which is comprised of two monomer polypeptide constructs as mentioned above, and which comprises three TTSEs or a multiplum of three TTSEs, or which is comprised of three monomer polypeptide constructs.