The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 22, 2012

Filed:

Jun. 21, 2006
Applicants:

John Demattei, San Diego, CA (US);

Sagar Shakya, Longmont, CO (US);

Paul J. Nichols, Boulder, CO (US);

Bradley R. Barnett, Boulder, CO (US);

Bruno P. Hache, Boulder, CO (US);

Matthew Charles Evans, Macclesfield, GB;

James Gair Ford, Macclesfield, GB;

John Leonard, Macclesfield, GB;

Inventors:

John DeMattei, San Diego, CA (US);

Sagar Shakya, Longmont, CO (US);

Paul J. Nichols, Boulder, CO (US);

Bradley R. Barnett, Boulder, CO (US);

Bruno P. Hache, Boulder, CO (US);

Matthew Charles Evans, Macclesfield, GB;

James Gair Ford, Macclesfield, GB;

John Leonard, Macclesfield, GB;

Assignees:

Array BioPharma Inc., Boulder, CO (US);

AstraZeneca AB, Sodertalje, SE;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 235/08 (2006.01);
U.S. Cl.
CPC ...
Abstract

Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ia-2 and their synthetic intermediates: wherein X, X, X, R, Rand Rare as defined herein. Compounds of Formula Ia-2 and their synthetic intermediates can be used to prepare heterocyclic derivatives such as benzimidazole derivatives.


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