The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2012
Filed:
Sep. 15, 2006
Jingkang Wang, Tianjin, CN;
Yuxin Qian, Shenzhen, CN;
Meijing Zhang, Tianjin, CN;
Jiehua Wu, Tianjin, CN;
Zhan'ao Yang, Shenzhen, CN;
Jingkang Wang, Tianjin, CN;
Yuxin Qian, Shenzhen, CN;
Meijing Zhang, Tianjin, CN;
Jiehua Wu, Tianjin, CN;
Zhan'ao Yang, Shenzhen, CN;
Tianjin University, Nankai District, Tianjin, CN;
Shenzhen Gosun Pharmaceutical Co., Ltd., Futian District, Shenzhen, CN;
Abstract
The present invention relates to cefazolin sodium pentahydrate crystal and a method for assembly and preparation of the crystal molecule. The cefazolin sodium pentahydrate crystal molecule contains five water molecules, orthorhombic system, space group of C222(1), in which sodium ion is bonded to the cefazolin molecule with a coordinate bond. The method for assembly and preparation of cefazolin sodium pentahydrate crystal molecule are: adding a solvent to a reactor equipped with a jacket, adding cefazolin acid and a sodium salt, heating until the reaction solution is clear, stirring continuously, adjusting pH, upon the completion of the reaction, transferring the liquid into a jacketed crystallizer, adding crystal seeds or nucleating spontaneously, controlling cooling, slowly adding a antisolvent. The particle size of cefazolin sodium pentahydrate crystal according to the present invention is adjustable, and the distribution of particle size is concentrated, the product has good flowability, smooth surface, high crystallinity, good stability, and rapid dissolving rate.