The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 08, 2012

Filed:

Apr. 23, 2009
Applicants:

Richard R. Bott, Burlingame, CA (US);

Marguerite A. Cervin, Redwood City, CA (US);

James T. Kellis, Jr., Palo Alto, CA (US);

Joseph C. Mcauliffe, Sunnyvale, CA (US);

Andrei Miasnikov, Mountain View, CA (US);

Caroline M. Peres, Palo Alto, CA (US);

Christopher Lee Rife, Redwood City, CA (US);

Derek H. Wells, Palo Alto, CA (US);

Walter Weyler, San Francisco, CA (US);

Gregory M. Whited, Belmont, CA (US);

Inventors:

Richard R. Bott, Burlingame, CA (US);

Marguerite A. Cervin, Redwood City, CA (US);

James T. Kellis, Jr., Palo Alto, CA (US);

Joseph C. McAuliffe, Sunnyvale, CA (US);

Andrei Miasnikov, Mountain View, CA (US);

Caroline M. Peres, Palo Alto, CA (US);

Christopher Lee Rife, Redwood City, CA (US);

Derek H. Wells, Palo Alto, CA (US);

Walter Weyler, San Francisco, CA (US);

Gregory M. Whited, Belmont, CA (US);

Assignee:

Danisco US Inc., Palo Alto, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); C12N 15/09 (2006.01); C12N 15/00 (2006.01); C12N 1/20 (2006.01); C12P 5/02 (2006.01); C07H 21/04 (2006.01); C07K 1/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.


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