The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2012
Filed:
Mar. 03, 2009
Adam C. Finnefrock, Berwyn, PA (US);
Tong-ming Fu, Maple Glen, PA (US);
Daniel C. Freed, Limerick, PA (US);
Danilo R. Casimiro, Harleysville, PA (US);
Fengsheng LI, Scarsdale, NY (US);
Aimin Tang, Lansdale, PA (US);
Adam C. Finnefrock, Berwyn, PA (US);
Tong-Ming Fu, Maple Glen, PA (US);
Daniel C. Freed, Limerick, PA (US);
Danilo R. Casimiro, Harleysville, PA (US);
Fengsheng Li, Scarsdale, NY (US);
Aimin Tang, Lansdale, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.