The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2012
Filed:
Nov. 04, 2010
José L. Boyer, Chapel Hill, NC (US);
Sammy R. Shaver, Chapel Hill, NC (US);
James G. Douglass, Iii, Apex, NC (US);
Catherine C. Redick, Durham, NC (US);
José L. Boyer, Chapel Hill, NC (US);
Sammy R. Shaver, Chapel Hill, NC (US);
James G. Douglass, III, Apex, NC (US);
Catherine C. Redick, Durham, NC (US);
Inspire Pharmaceuticals, Inc., Whitehouse Station, NJ (US);
Abstract
This invention is directed to a method of enhancing or facilitating the clearance or the lung mucus secretions in a subject. This invention is also directed to a method of facilitating the hydration of the lung mucus secretions in a subject. This invention is further directed to a method of preventing or treating diseases or conditions associated with impaired lung or airway function in a human or other mammal. The method comprises administering to a subject a pharmaceutical composition comprising a therapeutic effective amount of P2Yreceptor agonist compound, wherein said amount is effective to activate the P2Yreceptors on the luminal surface of lung epithelia. The P2Yreceptor agonist compounds useful for this invention include mononucleoside 5'-diphosphates, dinucleoside monophosphate, dinucleoside diphosphates, or dinucleoside triphosphates of general Formula I, or salts, solvates, hydrates thereof. This invention is also directed to novel P2Yreceptor agonist compounds.