The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2012
Filed:
Oct. 19, 2005
Deb K Chatterjee, Potomac, MD (US);
Kalavathy Sitaraman, Frederick, MD (US);
James L Hartley, Frederick, MD (US);
Cassio Baptista, Frederick, MD (US);
David J Munroe, Frederick, MD (US);
Deb K Chatterjee, Potomac, MD (US);
Kalavathy Sitaraman, Frederick, MD (US);
James L Hartley, Frederick, MD (US);
Cassio Baptista, Frederick, MD (US);
David J Munroe, Frederick, MD (US);
Abstract
The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protein comprising a polypeptide of interest and a DNA-binding protein that binds the protein-binding domain, and one or more fusion proteins produced from the multiple nucleic acid molecules. Each fusion protein is immobilized on the substrate via binding to a nucleic acid sequence comprising the protein-binding domain present on the nucleic acid molecule from which the fusion protein is produced or on the substrate. The invention also provides a method of analyzing protein interactions with, for example, other proteins, lipids and drugs.