The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2012
Filed:
Jun. 02, 2004
Stephen H Friend, Seattle, WA (US);
Michele a Cleary, Jamison, PA (US);
Kristopher a Kilian, Savoy, IL (US);
Ernest M Coffey, Shoreline, WA (US);
Gregory J Hannon, Huntington, NY (US);
Patrick Paddison, Seattle, WA (US);
Stephen H Friend, Seattle, WA (US);
Michele A Cleary, Jamison, PA (US);
Kristopher A Kilian, Savoy, IL (US);
Ernest M Coffey, Shoreline, WA (US);
Gregory J Hannon, Huntington, NY (US);
Patrick Paddison, Seattle, WA (US);
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The present invention provides methods of making a population of nucleic acid molecules, wherein each nucleic acid molecule comprises a predetermined nucleic acid sequence, each of said methods comprising the steps of: (a) synthesizing, on a substrate, a population of nucleic acid molecules wherein: i) each synthesized nucleic acid molecule comprises a predetermined nucleic acid sequence; and ii) each synthesized nucleic acid molecule is localized to a defined area of said substrate; (b) harvesting said population of synthesized nucleic acid molecules from said substrate to yield harvested nucleic acid molecules; and (c) introducing said harvested nucleic acid molecules into vector molecules.