The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2012
Filed:
Jan. 31, 2006
Applicants:
Tong Zhou, Birmingham, AL (US);
Robert P. Kimberly, Birmingham, AL (US);
Inventors:
Tong Zhou, Birmingham, AL (US);
Robert P. Kimberly, Birmingham, AL (US);
Assignee:
The UAB Research Foundation, Birmingham, AL (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); G01N 33/566 (2006.01); C07K 14/715 (2006.01); C07K 14/47 (2006.01); C07K 14/52 (2006.01);
U.S. Cl.
CPC ...
Abstract
Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.