The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2012
Filed:
May. 05, 2010
Charles Allerson, San Diego, CA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Charles Allerson, San Diego, CA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Isis Pharmaceuticals, Inc, Carlsbad, CA (US);
Abstract
Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification.