The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2012
Filed:
Mar. 28, 2003
Eugenio Ferrari, Palo Alto, CA (US);
Carole Harbison, Palo Alto, CA (US);
M. Harunur Rashid, Palo Alto, CA (US);
Walter Weyler, Palo Alto, CA (US);
Eugenio Ferrari, Palo Alto, CA (US);
Carole Harbison, Palo Alto, CA (US);
M. Harunur Rashid, Palo Alto, CA (US);
Walter Weyler, Palo Alto, CA (US);
Danisco US Inc., Palo Alto, CA (US);
Abstract
The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such asspecies having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from thechromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-typehost chromosome.