The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2012
Filed:
Jun. 20, 2006
Chetana Rao-naik, Walnut Creek, CA (US);
David John King, Belmont, CA (US);
Jie Liu, Palo Alto, CA (US);
Haichun Huang, Fremont, CA (US);
David B. Passmore, San Carlos, CA (US);
Alasdair Fraser Bell, Mountain View, CA (US);
Josephine M. Cardarelli, San Carlos, CA (US);
Chin Pan, Los Altos, CA (US);
To Uyen Thi DO, Sacramento, CA (US);
Sharline Chen, Sunnyvale, CA (US);
Dawn M. Tanamachi, Milpitas, CA (US);
Chetana Rao-Naik, Walnut Creek, CA (US);
David John King, Belmont, CA (US);
Jie Liu, Palo Alto, CA (US);
Haichun Huang, Fremont, CA (US);
David B. Passmore, San Carlos, CA (US);
Alasdair Fraser Bell, Mountain View, CA (US);
Josephine M. Cardarelli, San Carlos, CA (US);
Chin Pan, Los Altos, CA (US);
To Uyen Thi Do, Sacramento, CA (US);
Sharline Chen, Sunnyvale, CA (US);
Dawn M. Tanamachi, Milpitas, CA (US);
Medarex, Inc., Princeton, NJ (US);
Abstract
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.