The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2012
Filed:
Feb. 04, 2008
Lisa M. Larkin, Ann Arbor, MI (US);
Ellen M. Arruda, Ann Arbor, MI (US);
Sarah Calve, Chicago, IL (US);
Tatiana Y. Kostriminova, Schererville, IN (US);
Lisa M. Larkin, Ann Arbor, MI (US);
Ellen M. Arruda, Ann Arbor, MI (US);
Sarah Calve, Chicago, IL (US);
Tatiana Y. Kostriminova, Schererville, IN (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
A system and method for forming a skeletal muscle construct include primary muscle cells provided on a substrate without disposing the cells within an exogenous scaffold, the cells cultured in vitro such that the cells form a confluent monolayer; at least two anchors secured to the monolayer in spaced relationship; and at least one secondary tissue, such as neural or tendon tissue, provided in contact with the monolayer such that the monolayer detaches from the substrate and self-organizes to at least partially surround the at least one secondary tissue, thereby forming a three-dimensional skeletal muscle construct having a functional interface with the secondary tissue.