The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2012
Filed:
Jun. 04, 2009
Susan M. Freier, Carlsbad, CA (US);
Rosanne M. Crooke, Carlsbad, CA (US);
Mark J. Graham, Carlsbad, CA (US);
Kristina L. Lemonidis, Carlsbad, CA (US);
Sanjay Bhanot, Carlsbad, CA (US);
Diane Tribble, Carlsbad, CA (US);
Andrew T. Watt, Carlsbad, CA (US);
Susan M. Freier, Carlsbad, CA (US);
Rosanne M. Crooke, Carlsbad, CA (US);
Mark J. Graham, Carlsbad, CA (US);
Kristina L. Lemonidis, Carlsbad, CA (US);
Sanjay Bhanot, Carlsbad, CA (US);
Diane Tribble, Carlsbad, CA (US);
Andrew T. Watt, Carlsbad, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.