The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2012
Filed:
Apr. 13, 2007
Han-chung Wu, Taipei, TW;
Chin-tarng Lin, Taipei, TW;
Tong-young Lee, Taipei, TW;
Szu-yao Kuo, Taipei, TW;
Han-Chung Wu, Taipei, TW;
Chin-Tarng Lin, Taipei, TW;
Tong-Young Lee, Taipei, TW;
Szu-Yao Kuo, Taipei, TW;
Academia Sinica, Taipei, TW;
National Taiwan University, Taipei, TW;
Abstract
The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCID mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCID mice.