The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Aug. 23, 2005
Herbert Grieb, Malsch, DE;
Karl-heinz Kirchberg, Karlsruhe, DE;
Edmund Linzenkirchner, Eggenstein-Leopoldshafen, DE;
Ingrid Maes, Zwijndrecht, BE;
Bernd-markus Pfeiffer, Wörth, DE;
Herbert Grieb, Malsch, DE;
Karl-Heinz Kirchberg, Karlsruhe, DE;
Edmund Linzenkirchner, Eggenstein-Leopoldshafen, DE;
Ingrid Maes, Zwijndrecht, BE;
Bernd-Markus Pfeiffer, Wörth, DE;
Siemens Aktiengesellschaft, Munich, DE;
Abstract
The invention relates to the online regulation of a batch process in a bioreactor. According to the invention, spectra of the actual charge in the bioreactor are recorded at successive points during the running batch process. A measuring vector is produced, for each spectrum, in the low-dimensional main constituent region by the main constituent analysis of the high-dimensional spectra. The deviation is calculated between the measuring vector and a corresponding vector of a nominal trajectory consisting of measuring vectors of a reference charge, which are determined in an earlier batch process, and at least one adjustment operation for the batch process is determined and carried out according to said deviation. The direction of the adjustment operation is maintained when the deviation determined from one point to the next decreases, and modified when the deviation determined from one point to the next remains the same or increases.