IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8076324 B1

PDFFull Text
Date of Patent:
Dec. 13, 2011

Filed:

Dec. 03, 2009

Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them

Applicants:

Thomas Bohme, Nauheim, DE;

Uwe Gerlach, Hattersheim, DE;

Dirk Gretzke, Frankfurt, DE;

Heinz-werner Kleemann, Bischofsheim, DE;

Stefania Pfeiffer-marek, Frankfurt, DE;

Henning Vollert, Bad Segeberg, DE;

Jean-michel Altenburger, Saint Remy les Chevreuse, FR;

Sergio Mallart, Orsay, FR;

Inventors:

Thomas Bohme, Nauheim, DE;

Uwe Gerlach, Hattersheim, DE;

Dirk Gretzke, Frankfurt, DE;

Heinz-Werner Kleemann, Bischofsheim, DE;

Stefania Pfeiffer-Marek, Frankfurt, DE;

Henning Vollert, Bad Segeberg, DE;

Jean-Michel Altenburger, Saint Remy les Chevreuse, FR;

Sergio Mallart, Orsay, FR;

Assignee:

Sanofi-Aventis, Paris, FR;

Attorneys:

Serena Farquharson-Torres

Scully, Scott, Murphy & Presser, P.C.

Primary Examiner:

Sun Jae Loewe

Int. Cl.
CPC ...
A61P 9/00 (2006.01); A61P 9/06 (2006.01); A61K 31/55 (2006.01); A61K 31/444 (2006.01); A61K 31/506 (2006.01); A61K 31/404 (2006.01); A61K 31/19 (2006.01); A61K 31/415 (2006.01); A61K 31/426 (2006.01); A61K 31/4184 (2006.01); A61K 31/44 (2006.01); A61K 31/343 (2006.01); A61K 31/4196 (2006.01); C07C 62/00 (2006.01); C07D 213/55 (2006.01); C07D 317/46 (2006.01); C07D 215/14 (2006.01); C07D 487/02 (2006.01); C07D 231/12 (2006.01); C07D 277/30 (2006.01); C07D 239/02 (2006.01); C07D 209/04 (2006.01); C07D 235/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar, Ar, Rand Rhave the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

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