The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2011
Filed:
Dec. 17, 2007
John W. Lampe, Cary, NC (US);
Paul S. Watson, Carrboro, NC (US);
David J. Slade, Durham, NC (US);
Ward M. Peterson, Morrisville, NC (US);
Christopher S. Crean, Pittsboro, NC (US);
Jason L. Vittitow, Durham, NC (US);
Jonathan Bryan Decamp, Raleigh, NC (US);
Nicholas F. Pelz, Durham, NC (US);
John W. Lampe, Cary, NC (US);
Paul S. Watson, Carrboro, NC (US);
David J. Slade, Durham, NC (US);
Ward M. Peterson, Morrisville, NC (US);
Christopher S. Crean, Pittsboro, NC (US);
Jason L. Vittitow, Durham, NC (US);
Jonathan Bryan DeCamp, Raleigh, NC (US);
Nicholas F. Pelz, Durham, NC (US);
Inspire Pharmaceuticals, Inc., Whitehouse Station, NJ (US);
Abstract
The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions.