The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2011
Filed:
Apr. 16, 2008
Kenji Soejima, Kikuchi-gun, JP;
Noriko Mimura, Kikuchi-gun, JP;
Hiroaki Maeda, Kikuchi-gun, JP;
Chikateru Nozaki, Kikuchi-gun, JP;
Takayoshi Hamamoto, Kumamoto, JP;
Tomohiro Nakagaki, Kumamoto, JP;
Kenji Soejima, Kikuchi-gun, JP;
Noriko Mimura, Kikuchi-gun, JP;
Hiroaki Maeda, Kikuchi-gun, JP;
Chikateru Nozaki, Kikuchi-gun, JP;
Takayoshi Hamamoto, Kumamoto, JP;
Tomohiro Nakagaki, Kumamoto, JP;
Abstract
This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val (SEQ ID NO: 2), and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.