The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2011
Filed:
Apr. 24, 2007
Arie Pieter Otte, Amersfoort, NL;
Henricus J. M. Van Blokland, Wijdewormer, NL;
Theodorus H. J. Kwaks, Amsterdam, NL;
Richard G. A. B. Sewalt, Amhem, NL;
Arie Pieter Otte, Amersfoort, NL;
Henricus J. M. van Blokland, Wijdewormer, NL;
Theodorus H. J. Kwaks, Amsterdam, NL;
Richard G. A. B. Sewalt, Amhem, NL;
Chromagenics B.V., Leiden, NL;
Abstract
The invention provides a DNA molecule comprising an open reading frame sequence that encodes a selectable marker polypeptide, wherein said DNA molecule in the coding strand comprises a translation start sequence for the selectable marker polypeptide having a GTG startcodon or a TTG startcodon, and wherein the open reading frame sequence that encodes the selectable marker protein has been mutated to replace at least half of its CpG dinucleotides as compared to the native open reading frame sequence that encodes the selectable marker protein.