The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2011
Filed:
Jul. 15, 2005
Aaron Adriaan Winkler, The Hague, NL;
Sipko Maarten Kuyper, Delft, NL;
Wilhelmus Theodorus Antonius Maria DE Laat, Breda, NL;
Johannes Pieter Van Dijken, Leidschendam, NL;
Jacobus Thomas Pronk, Schipluiden, NL;
Aaron Adriaan Winkler, The Hague, NL;
Sipko Maarten Kuyper, Delft, NL;
Wilhelmus Theodorus Antonius Maria De Laat, Breda, NL;
Johannes Pieter Van Dijken, Leidschendam, NL;
Jacobus Thomas Pronk, Schipluiden, NL;
Techische Universiteit Delft, Delft, NL;
Abstract
The present invention relates to further genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers the host cell the ability of isomerizing xylose to xylulose. The further genetic modifications are aimed at improving the efficiency of xylose metabolism and include e.g. reduction of unspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.