The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2011
Filed:
Dec. 04, 2006
Michael Etzerodt, Hinnerup, DK;
Thor Las Holtet, Rønde, DK;
Niels Jonas Heilskov Graversen, Åbyhøj, DK;
Hans Christian Thøgersen, Mundelstrup, DK;
Michael Etzerodt, Hinnerup, DK;
Thor Las Holtet, Rønde, DK;
Niels Jonas Heilskov Graversen, Åbyhøj, DK;
Hans Christian Thøgersen, Mundelstrup, DK;
Anaphore, Inc., San Diego, CA (US);
Abstract
The present invention provides novel polypeptides having the scaffold structure of a C-type lectin-like domain (CTLD) and a randomized loop region for specifically binding a variety of target compounds and also provides nucleic acids encoding the polypeptides. The present invention further provides combinatorial CTLD libraries, methods for constructing the libraries, and methods for screening the libraries to identify and isolate the novel CTLD polypeptides. Specifically, the invention provides libraries of nucleic acids encoding polypeptides having a scaffold CTLD with a randomized loop region, as well as nucleic acid sequences, vectors, and methods for preparing and expressing the libraries. Exemplary nucleic acids useful in the combinatorial libraries are derived from tetranectin and other proteins having a CTLD.