The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2011
Filed:
Sep. 15, 2008
William D. Tracey, Jr., Chapel Hill, NC (US);
Nancy Stearns, Durham, NC (US);
Lixian Zhong, Durham, NC (US);
Yifan Xu, New York, NY (US);
Jason Caldwell, Durham, NC (US);
Allison Weaver, Cary, NC (US);
Angela Hofhine, Durham, NC (US);
William D. Tracey, Jr., Chapel Hill, NC (US);
Nancy Stearns, Durham, NC (US);
Lixian Zhong, Durham, NC (US);
Yifan Xu, New York, NY (US);
Jason Caldwell, Durham, NC (US);
Allison Weaver, Cary, NC (US);
Angela Hofhine, Durham, NC (US);
Duke University, Durham, NC (US);
Abstract
Methods for identifying a candidate compound with an ability to modulate cation transport through a transient receptor potential (TRP) channel in a cell are disclosed. The methods can include (a) providing a cell expressing a recombinant nucleic acid sequence encoding an transient receptor potential (TRP) channel gene product or a functional fragment or derivative thereof; (b) contacting the cell with the candidate compound; (c) comparing cation transport in the cell in the absence of the candidate compound with cation transport in the cell in the presence of the candidate compound; and (d) identifying a candidate compound through the comparing step that modulates cation transport in the cell through the transient receptor potential (TRP) channel. Also disclosed are nucleic acid and amino acid sequences for insect TRP channel gene products, antibodies that bind to the disclosed TRP channels, and recombinant host cells the include the disclosed biosequences.