The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2011
Filed:
Feb. 06, 2008
Zhiqiang an, Ambler, PA (US);
Fang Chen, North Wales, PA (US);
John E. Fisher, Jenkintown, PA (US);
Helmut Glantschnig, Schwenksville, PA (US);
Donald B. Kimmel, Doylestown, PA (US);
Alfred A. Reszka, New Hope, PA (US);
Fubao Wang, Dresher, PA (US);
Zhiqiang An, Ambler, PA (US);
Fang Chen, North Wales, PA (US);
John E. Fisher, Jenkintown, PA (US);
Helmut Glantschnig, Schwenksville, PA (US);
Donald B. Kimmel, Doylestown, PA (US);
Alfred A. Reszka, New Hope, PA (US);
Fubao Wang, Dresher, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.