The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2011
Filed:
Sep. 10, 2007
Isidore Rigoutsos, Astoria, NY (US);
Peter Riek, West Pennant Hills, AU;
Robert M. Graham, Pymble, AU;
Jiri Novotny, Fairlight, AU;
Isidore Rigoutsos, Astoria, NY (US);
Peter Riek, West Pennant Hills, AU;
Robert M. Graham, Pymble, AU;
Jiri Novotny, Fairlight, AU;
International Business Machines Corporation, Armonk, NY (US);
Abstract
The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a 'local' phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.