The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2011
Filed:
Jun. 09, 2006
Matthew L. Albert, Paris, FR;
Nina Bhardwaj, West Orange, NJ (US);
Ralph M. Steinman, Westport, CT (US);
Kayo Inaba, Kyoto, JP;
Robert Darnell, Pelham, NY (US);
Matthew L. Albert, Paris, FR;
Nina Bhardwaj, West Orange, NJ (US);
Ralph M. Steinman, Westport, CT (US);
Kayo Inaba, Kyoto, JP;
Robert Darnell, Pelham, NY (US);
The Rockefeller University, New York, NY (US);
Abstract
This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.