The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2011
Filed:
Aug. 22, 2000
Jonathan Schneck, Silver Spring, MD (US);
Sean O'herrin, Baltimore, MD (US);
Michael S. Lebowitz, Pikesville, MD (US);
Abdel Hamad, Ellicott City, MD (US);
Jonathan Schneck, Silver Spring, MD (US);
Sean O'Herrin, Baltimore, MD (US);
Michael S. Lebowitz, Pikesville, MD (US);
Abdel Hamad, Ellicott City, MD (US);
Johns Hopkins University, Baltimore, MD (US);
Abstract
Compositions comprising a cell in which a molecular complex with high affinity for its cognate ligand is bound to the surface of the cell are provided. To form the molecular complexes, extracellular domains of transmembrane heterodimeric proteins, particularly T cell receptor and major histocompatibility complex proteins, can be covalently linked to the heavy and light chains of immunoglobulin molecules. The molecular complexes can be used, inter alia, to detect and regulate antigen-specific T cells and as therapeutic agents for treating disorders involving immune system regulation, such as allergies, autoimmune diseases, tumors, infections, and transplant rejection. Optionally, identical antigenic peptides can be bound to each ligand binding site of a molecular complex.