The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2011
Filed:
Nov. 15, 2004
Henri Rainer Nordlund, Lempäälä, FI;
Olli Heikki Laitinen, Pirkkala, FI;
Vesa Pekka Hytönen, Ruutana, FI;
Markku Sakari Kulomaa, Tampere, FI;
Henri Rainer Nordlund, Lempäälä, FI;
Olli Heikki Laitinen, Pirkkala, FI;
Vesa Pekka Hytönen, Ruutana, FI;
Markku Sakari Kulomaa, Tampere, FI;
Orion Diagnostica Oy, Espoo, FI;
Abstract
Two circularly permuted avidin monomers arc designed. The circularly permuted monomers are fused and the resulting fusion peptides (dcAvd) form a pseudo-tetrameric dual-chain avidin, which is biologically active in biotin binding and shows similar structural characteristics as wild-type avidin. The dcAvd makes the development of dual-affinity avidins possible by allowing the adjustment of the ligand binding properties in the half of the binding sites differently than in the rest of the sites. The present invention provides further a single-chain avidin (scAvd) where two dcAvd-molecules are fused together via a linker to form a single polypeptide with four binding sites for biotin or other ligand.