The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2011
Filed:
Jun. 23, 2005
Shawn Defrees, North Wales, PA (US);
David A. Zopf, Wayne, PA (US);
Zhi-guang Wang, Dresher, PA (US);
Caryn Bowe, Doylestown, PA (US);
Shawn DeFrees, North Wales, PA (US);
David A. Zopf, Wayne, PA (US);
Zhi-Guang Wang, Dresher, PA (US);
Caryn Bowe, Doylestown, PA (US);
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.