The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2011
Filed:
Feb. 20, 1998
Carl H. June, Rockville, MD (US);
Richard G. Carroll, Gaithersburg, MD (US);
James L. Riley, Elkridge, MD (US);
Daniel C. St. Louis, Rockville, MD (US);
Bruce L. Levine, Cherry Hill, NJ (US);
Carl H. June, Rockville, MD (US);
Richard G. Carroll, Gaithersburg, MD (US);
James L. Riley, Elkridge, MD (US);
Daniel C. St. Louis, Rockville, MD (US);
Bruce L. Levine, Cherry Hill, NJ (US);
The United States of America as represented by the Secretary of the Navy, Washington, DC (US);
Abstract
Methods for modulating HIV-1 fusion cofactor expression by manipulating an accessory molecule on the surface of T cells, such as CD28, are described. The invention encompasses methods for modulating HIV-1 fusion cofactor expression by stimulating or inhibiting one or more intracellular signals which result from ligation of a surface receptor on a T cell which binds a costimulatory molecule. In one embodiment, expression of an HIV-1 fusion cofactor, such as CCR5, is downregulated by stimulating a CD28-associated signal in the T cell.