The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2011
Filed:
Oct. 29, 2002
Jeffrey A. Ledbetter, Seattle, WA (US);
Martha S. Hayden, Everett, WA (US);
Peter S. Linsley, Seattle, WA (US);
Jurgen Bajorath, Lynnwood, WA (US);
H. Perry Fell, Redmond, WA (US);
Lisa K. Gilliland, Oxford, GB;
Jeffrey A. Ledbetter, Seattle, WA (US);
Martha S. Hayden, Everett, WA (US);
Peter S. Linsley, Seattle, WA (US);
Jurgen Bajorath, Lynnwood, WA (US);
H. Perry Fell, Redmond, WA (US);
Lisa K. Gilliland, Oxford, GB;
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention provides an expression vector encoding monospecific or bispecific fusion protein. In one embodiment the expression vector encodes a monospecific fusion protein, which vector comprises a recombinant monospecific single chain cassette comprising a DNA sequence encoding a first binding domain capable of binding a cell surface antigen. In another embodiment the expression vector encodes a bispecific fusion protein, which vector comprises a recombinant bispecific single chain cassette comprising a DNA sequence encoding a first binding domain capable of binding a cell surface antigen and a DNA sequence encoding a second binding domain capable of binding a cell surface antigen, each domain capable of binding a different antigen. The present invention also provides a method for producing a biologically active monospecific or bispecific fusion protein in a mammalian cell.