The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2011
Filed:
Aug. 21, 2007
Mark A. Ashwell, Carlisle, MA (US);
Manish Tandon, Framingham, MA (US);
Jean-marc Lapierre, Pelham, NH (US);
Syed Ali, North Andover, MA (US);
David Vensel, Somerville, MA (US);
Chiang J. LI, Cambridge, MA (US);
Mark A. Ashwell, Carlisle, MA (US);
Manish Tandon, Framingham, MA (US);
Jean-Marc Lapierre, Pelham, NH (US);
Syed Ali, North Andover, MA (US);
David Vensel, Somerville, MA (US);
Chiang J. Li, Cambridge, MA (US);
ArQule, Inc., Woburn, MA (US);
Abstract
The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as β-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).