The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2011
Filed:
Aug. 12, 2005
Rakesh Tuli, Uttar Pradesh, IN;
Samir Vishwanath Sawant, Uttar Pradesh, IN;
Shadma Ashraf, Uttar Pradesh, IN;
Pradhyumna Kumar Singh, Uttar Pradesh, IN;
Dinesh Kumar Yadav, Uttar Pradesh, IN;
Mohammad Shahnawaz, Uttar Pradesh, IN;
Satish Mishra, Uttar Pradesh, IN;
Rakesh Tuli, Uttar Pradesh, IN;
Samir Vishwanath Sawant, Uttar Pradesh, IN;
Shadma Ashraf, Uttar Pradesh, IN;
Pradhyumna Kumar Singh, Uttar Pradesh, IN;
Dinesh Kumar Yadav, Uttar Pradesh, IN;
Mohammad Shahnawaz, Uttar Pradesh, IN;
Satish Mishra, Uttar Pradesh, IN;
Council of Scientific and Indistrial Research, New Delhi, IN;
Unichem Laboratories Ltd., Mumbai, IN;
Indian Veterinary Research Institute, Izatnagar, IN;
Abstract
A novel chimeric protein of rabies virus designed to express a chimeric G protein at a high level in transgenic plants. A gene was also designed and chemically synthesised to encode the chimeric G protein and expressed at high level in plant tissue. The gene was expressed in transgenic tobacco plants to examine its therapeutic efficacy against infection by rabies virus. The chimeric G protein was enriched in plant membranes. The BalbC mice were immunised with the plant leaf expressed G-protein. Plant derived chimeric G protein elicited higher immune response as compared to the commercial vaccine. The mice displayed protective immunity when they were challenged with live virus. Chimeric G protein expressed at high level in plant leaves was demonstrated to function as a commercially valuable subunit vaccine against rabies virus infection.