The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2011
Filed:
Nov. 01, 2006
William F. Dove, Madison, WI (US);
Michael N. Gould, Madison, WI (US);
Lawrence N. Kwong, Madison, WI (US);
James M. Amos-landgraf, Madison, WI (US);
Jill D. Haag, Mt. Horeb, WI (US);
William F. Dove, Madison, WI (US);
Michael N. Gould, Madison, WI (US);
Lawrence N. Kwong, Madison, WI (US);
James M. Amos-Landgraf, Madison, WI (US);
Jill D. Haag, Mt. Horeb, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
A rat with a disrupted Apc (adenomatous polyposis coli) gene is provided. The mutation can include an A to T transversion changing a lysine to a stop codon at codon 1137. Methods of generating the knockout rat are provided. Also provided is the offspring or progeny of that rat. In addition, methods of using these rats are provided, including methods for screening a carcinogen or a promoter of carcinogenesis, and methods for screening preventive and inhibitory agents of carcinogenesis.