The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Mar. 09, 2007
Mark William James Ferguson, Manchester, GB;
Phillip Mellors, Manchester, GB;
Hugh Gerard Laverty, Manchester, GB;
Nick Occleston, Manchester, GB;
Sharon O'kane, Manchester, GB;
Simon Higginbottom, Manchester, GB;
Mark William James Ferguson, Manchester, GB;
Phillip Mellors, Manchester, GB;
Hugh Gerard Laverty, Manchester, GB;
Nick Occleston, Manchester, GB;
Sharon O'Kane, Manchester, GB;
Simon Higginbottom, Manchester, GB;
Renovo Limited, Manchester, GB;
Abstract
The present invention concerns a method for folding a Transforming Growth Factor Beta, or a functional analogue thereof, into a dimeric, biologically active form. The method involves adding solubilized, unfolded monomeric growth factor to a solution containing 2-(cyclohexylamino)-ethanesulfonic acid (CHES) or a functional analogue thereof and a low molecular weight sulfhydryl/disulfide redox system. The solution is then incubated under conditions suitable for generating dimeric biologically active Transforming Growth Factor Beta.