The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Mar. 28, 2008
Kondamraj Birudaraj, Pine Brook, NJ (US);
Michael Thomas Brandl, Redwood City, CA (US);
Shridhar Hegde, Mountain View, CA (US);
Felix Sana, Sunnyvale, CA (US);
Dimitrios Stefanidis, Mountain View, CA (US);
Kondamraj Birudaraj, Pine Brook, NJ (US);
Michael Thomas Brandl, Redwood City, CA (US);
Shridhar Hegde, Mountain View, CA (US);
Felix Sana, Sunnyvale, CA (US);
Dimitrios Stefanidis, Mountain View, CA (US);
Roche Palo Alto LLC, South San Francisco, CA (US);
Abstract
The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate; hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.