The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2011
Filed:
Aug. 01, 2007
Tomasz Glinka, Cupertino, CA (US);
Keith Bostian, Atherton, CA (US);
Olga Lomovskaya, Mountain View, CA (US);
Mark Surber, San Diego, CA (US);
Dongxu Sun, Cupertino, CA (US);
Tomasz Glinka, Cupertino, CA (US);
Keith Bostian, Atherton, CA (US);
Olga Lomovskaya, Mountain View, CA (US);
Mark Surber, San Diego, CA (US);
Dongxu Sun, Cupertino, CA (US);
Mpex Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
Disclosed herein are Efflux Pump Inhibitor (EPI) compounds that can be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens. The EPI compounds are soft drugs which exhibit a reduced propensity for tissue accumulation. It is demonstrated that the EPIs can be used to increase the potency, decrease bacterial resistance and development of bacterial resistance, and increase killing effectivness of tigecycline. Also disclosed are methods of treatment and pharmaceutical compositions for co-administering tigecylcine with an EPI.