The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2011
Filed:
Aug. 09, 2005
Grace Christy Rani Royappa, La Jolla, CA (US);
Marilyn H. Perrin, La Jolla, CA (US);
Jean E. Rivier, La Jolla, CA (US);
Wylie W. Vale, Jr., La Jolla, CA (US);
Roland Riek, La Jolla, CA (US);
Grace Christy Rani Royappa, La Jolla, CA (US);
Marilyn H. Perrin, La Jolla, CA (US);
Jean E. Rivier, La Jolla, CA (US);
Wylie W. Vale, Jr., La Jolla, CA (US);
Roland Riek, La Jolla, CA (US);
Research Development Foundation, Carson City, NV (US);
Abstract
The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present invention also relates to a method for improving antagonists or agonists of CRFR2. The present invention also relates to the three-dimensional structure of CRFR2 as representative of the B1 GPCR subfamily and its use as a basis for rational drug design of antagonist or agonists of B1 GPCRs.